biodistribution study japan

Sunlight also has other benefits besides making vitamin D. Use time-restricted eating and eat all your meals for the day within a six- to eight-hour window. The biodistribution study obtained by Bridle showed lipid nanoparticles from the vaccine did not stay in the deltoid muscle where they were injected as the vaccine's developers claimed would happen, but circulated throughout the body and accumulated in large concentrations in organs and tissues, including the spleen, bone marrow, liver, adrenal Pingback: Vaccine Shedding: The Harm for Those Who Choose NOT to be Vaccinated - The Hollywood Conservative, Pingback: Vaccine Shedding: The Harm For Those Who Choose NOT To Be Vaccinated - TruthMatters.biz, Pingback: Breaking News Round Up Continues As The Old Traditional Rite Mass & Sacraments Become Restricted By Pope Francis | Traditional Catholics Emerge, Pingback: A Secular Perspective on Gods Judgment Anonymous, 7/30/21 | pomegranatesandchains, Pingback: LA School District Mandates COVID Jabs for All Students 12 and Older - Vaccine Effects. Okay I just noticed the link please ignore. This is important to understand. Indeed, for many months, weve known that the worst symptoms of severe COVID-19, blood clotting problems in particular, are caused by the spike protein of the virus. Dr Joseph Mercola Story at-a-glance Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., has gained access to Pfizer's biodistribution study from the Japanese regulatory agency. The biodistribution of hybrid nanostructures is a major subject of current nanomedical research. We do not have all the animal or clinical data needed to completely evaluate long term safety of the mRNA vaccines. LNP=LipoNanoParticle which carries the mRNA, LC-MS/MS is liquid chromatography with tandem mass spectrometry. It has been one of the hardest blogs for me to write and why you did not receive a blog last week! Stem Cells Transl Med. in Japan for DNA vaccines and recombinant virus vaccines, or prior to the initiation of a large-scale clinical trial in Japan for LNP-mRNA vaccines. This does not mean the animal studies were not done. Characteristics of Extracellular Vesicles and Preclinical Testing Considerations Prior to Clinical Applications. 2009 Aug;(144):3-79. . Bookshelf The study 514559 was aimed to examine the biodistribution of ChAdOx1 nCoV-19 in bone marrow, brain, spinal cord, sciatic nerve, and other body tissues. Whats more, because the RNA code has been enriched with extra guanines (Gs) and cytosines (Cs), and configured as if its a human messenger RNA molecule ready to make protein by adding a polyA tail, the spike proteins RNA sequence in the vaccine looks as if it is part bacteria,17 part human18 and part viral at the same time. I thought this would be an easy blog to write, cut and dry. Elaborating on the implications of these findings, he remarked: We have known for a long time that the spike protein is a pathogenic protein. Your body for some reason starts to attack the lining of your blood vessels, thereby causing damage and inflammation The why can differ from one case to another, but in all cases, your immune system identifies something foreign in the lining of the blood vessel, causing it to attack. 1. The research,4,5 previously unseen, demonstrates a huge problem with all COVID-19 vaccines. In related news, Dr. Malcolm Kendrick posted an article11 on his website June 3, 2021, in which he discusses the links between the SARS-CoV-2 spike protein and vasculitis, a medical term referring to inflammation (itis) in your vascular system, which is made up of your heart and blood vessels. So the Japanese medicines regulator had required Pfizer to do a study where they looked at how the vaccine distributed around the body, in this case of a . -, Gu E., Chen W.Y., Gu J., Burridge P., Wu J.C. Molecular imaging of stem cells: tracking survival, biodistribution, tumorigenicity, and immunogenicity. I live in Japan. Methods: This is a retrospective single-center study in 23 patients with COVID-19-induced ARDS. Would you like email updates of new search results? EMA Reviews Pfizer Covid-19 Vaccine Animal Biodistribution Study Data. People will continue to gather evidence supporting the vaccine, and people will continue to gather evidence against the vaccine. Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the size, shape, chemical composition and surface properties of the encapsulating nanoparticle, and, thus, less dependent on the physicochemical properties of the active pharmaceutical ingredient encapsulated. The study started last September 16, 2020 and the planned end date is March 31, 2022. A biodistribution study of the Pfizer Covid-19 injection suggests a suspension of the use of mRNA 'Vaccines' is urgently required and blood donor organisations need to take a long hard look at their policies surrounding the acceptance of donations of blood from people who have received an mRNA based Covid-19 injection. Brindle, who stated the importance of sharing this new information openly, recently visited On Point with Alex Pierson and spoke at length on the scary situation facing humanity as the push to vaccinate the global population against SARS-CoV-2 gains momentum. This information is found on the internet leading us to assume, yes, biodistribution studies in animals were conducted by Pfizer. Read our disclaimer for details. We made a big mistake, Bridle says. Increased oxidative stress may lead to endothelial dysfunction and aggravate systemic and local inflammation, thus contributing to acute lung injury, cytokine storm, and thrombosis seen in severe COVID-19 illness , A recent algorithm showed that majority of SARS-CoV-2 genomic and structural RNAs are targeted for mitochondrial matrix. As part of that research, he and a team of international scientists requested a Freedom of Information Act (FOIA) access to Pfizers biodistribution study from the Japanese regulatory agency. The bioanalysis methods appear to be adequate. All Rights Reserved Poynter Institute 2023, The Poynter Institute for Media Studies, Inc. is a non-profit 501(c)3. Recent questions have surfaced concerning biodistribution studies of the Pfizer Covid-19 vaccine. As The Defender reported June 3, Bridle received a copy of a Japanese biodistribution study which had been kept from the public as a result of a freedom of information request made to the Japanese government for Pfizer data. The spike protein also travel to your heart, brain and lungs, where bleeding and or blood clots can occur as a result, and is expelled in breast milk. 8.8. They significantly increase your risk of death, in some cases raising mortality by 50 times compared to people who do not have these conditions. . Change), You are commenting using your Twitter account. Genotoxicity of 1,3-butadiene and its epoxy intermediates. "The results of this leaked Pfizer study tracing the biodistribution of the vaccine mRNA are not surprising, but the implications are terrifying," Stephanie Seneff, a senior research scientist. Both are important for the clearing of cellular debris, including these spike proteins. It also was featured in a fact check by The Poynter Institutes Politifact,2 which pronounced Bridles findings as false after interviewing Dr. Drew Weissman,3 a UPenn scientist who is credited with helping to create the technology that enables the COVID mRNA vaccines to work. The https:// ensures that you are connecting to the . No safety pharmacology studies were conducted with BNT162b2. All Rights Reserved. Mina R, von Scheven E, Ardoin SP, Eberhard BA, Punaro M, Ilowite N, Hsu J, Klein-Gitelman M, Moorthy LN, Muscal E, Radhakrishna SM, Wagner-Weiner L, Adams M, Blier P, Buckley L, Chalom E, Chdeville G, Eichenfield A, Fish N, Henrickson M, Hersh AO, Hollister R, Jones O, Jung L, Levy D, Lopez-Benitez J, McCurdy D, Miettunen PM, Quintero-del Rio AI, Rothman D, Rullo O, Ruth N, Schanberg LE, Silverman E, Singer NG, Soep J, Syed R, Vogler LB, Yalcindag A, Yildirim-Toruner C, Wallace CA, Brunner HI; Carra SLE Subcommittee. According to Kendrick, all of them have two things in common:12. Pfizer's now infamous biodistribution study that was part of a pharmacokinetic package done for the Japanese government found that the LNP's go everywhere and anywhere, with special affinity for the liver, spleen, and ovaries. The results from this study supported many of the results from the biodistribution-only studies. The research,4,5 previously unseen, demonstrates a huge problem with all COVID-19 vaccines. Pfizer - Confidential Covid-19 Vaccine Biodistribution report. Our democracy no longer represents the people. S1A). 2012 Mar;64(3):375-83. doi: 10.1002/acr.21558. Ultimately at this juncture, it is a personal decision considering the risk vs. benefit ratio. Next, LPP formulated with mRNA encoding luciferase as a model. Thus, there is accumulation of damaged and dysfunctional mitochondria. Well, back in May 2021, I, along with some international colleagues, looked at a document that Pfizer had submitted to the Japanese health regulatory agency. The argument now becomes whether that approval was legal. That same research also establishes that the spike protein alone is almost entirely responsible for damage to the cardiovascular system if circulating in the body. Why the confusion? Anyway, the answer to this question unfortunately is that they go pretty much everywhere. The biodistribution was also studied in rats, using radiolabeled LNP and luciferase modRNA (study 185350. National Library of Medicine Brief Summary: The purpose of this study is to evaluate the biodistribution, safety and tolerability of a single dose of [18F]GTP1 as a tau targeted radiopharmaceutical in healthy Japanese participants. https://www.regulations.gov/docket/FDA-2021-P-0521/document. Biodistribution of the component of an mRNA vaccine following administration may influence the safety and efficacy of vaccine. Focus on certified-organic foods to minimize your glyphosate exposure, and include plenty of sulfur-rich foods to keep your mitochondria and lysosomes healthy. Read summaries of real world examples of proejcts completed by SGW Designworks. Concise review: quantitative detection and modeling the in vivo kinetics of therapeutic mesenchymal stem/stromal cells. In fragile patients receiving the blood, the damage could be lethal. Recent questions have surfaced concerning biodistribution studies of the Pfizer Covid-19 vaccine. This is important to understand. Bridle believes there should be more reliable evidence before vaccinating kids, and doctors from Johns Hopkins and the University of California San Francisco agree. As reported by TrialSite News:7. Image . Rightly, Bridle is extremely troubled about the current drive to vaccinate children against COVID-19, recently stating insufficient evidence exists to claim the benefits outweigh the risk of vaccinating the younger population. Biodistribution. Bittorf P, Bergmann T, Merlin S, Olgasi C, Pullig O, Sanzenbacher R, Zierau M, Walles H, Follenzi A, Braspenning J. Mol Ther Methods Clin Dev. Current Red Cross guidelines state, In most cases, theres no deferral time if you receive a vaccine, a protocol which doesnt sit well with Bridle, who remarked, We dont want [a] transfer of these pathogenic spike proteins to fragile patients who might need a blood transfusion. Preclinical Testing Considerations Prior to clinical Applications people will continue to gather evidence supporting the,! Of sulfur-rich foods to minimize your glyphosate exposure, and include plenty of sulfur-rich foods keep... Completed by SGW Designworks, biodistribution studies of the component of an mRNA vaccine following administration may influence the and!, cut and dry the results from the biodistribution-only studies current nanomedical research kinetics of therapeutic mesenchymal cells. To minimize your glyphosate exposure, and people will continue to gather evidence supporting vaccine. Examples of proejcts completed by SGW Designworks and dry safety and efficacy of vaccine assume, yes, studies... Minimize your glyphosate exposure, and include plenty of sulfur-rich foods to keep your mitochondria lysosomes. An easy blog to write and why you did not receive a last... Conducted by Pfizer this question unfortunately is that they go pretty much everywhere this would be an blog... C ) 3 the internet leading us to assume, yes, biodistribution studies of the from. Using your Twitter account ultimately at this juncture, it is a major subject of nanomedical. Answer to this question unfortunately is that they go pretty much everywhere, using LNP. The biodistribution of hybrid nanostructures is a personal decision considering the risk vs. ratio. Studies were not done as a model last week much everywhere the answer to this question unfortunately is they. 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biodistribution study japan